PFAS Q&A: Analysis Methods

With thousands of PFAS compounds identified, how do laboratories determine which analytical methods will provide the most accurate detection?

Kyle Falk: Labs typically are going to be relying on EPA-approved methods when analyzing for PFAS, such as Method 533, which is designed to detect specific PFAS compounds in drinking water. Alternatively, Method 1633 is widely used for soil, groundwater, sediment, surface water, as well as wastewater. The choice depends on the media that is being sampled and the relevant regulatory requirements that you may be subject to.

For more complex matrices, like soil or biota, labs often will use liquid chromatography coupled with tandem mass spectrometry because it offers high sensitivity and specificity.